Bayard F, Louvet J P, Moatti J P, Smilovici W, Duguet L, Boulard C
J Gynecol Obstet Biol Reprod (Paris). 1975;4(7):915-26.
The authors have studied the long-term effects of combined oestrogen-progestogen on the secretion of gonadotrophins and on ovarian function. Estimation of the radio-immune levels of the plasma concentrations of the pituitary luteinizing hormone (LH), of oestradiol (E2), of progesterone (P) and of 20 alpha hydroxyprogesterone (20 alpha OHP) and of testosterone (T) served as a base for this study. A test cycle and 8 cycles in which a combination of 50 micrograms of ethinyl-oestradiol and 0.5 mg of norgestrel were administered were studied in 4 normal volunteer women. A pituitary stimulation test using 50 micrograms of gonadotrophin "releasing factor" (LH-RH) was given during the 7th cycle. Ovarian stimulation using human menopausal gonadotrophins (HMG) was given during the 8th cycle of treatment in 3 of the women and in 3 other subjects. Pituitary secretion of LH and ovarian secretion of E2 and P are partially inhibited. Pituitary response to the injection of LH-RH stays normal but 5 out 6 patients had no response to stimulation by gonadotrophins. These results allow us to conclude that the lowering of production of gonadotrophins during treatment with combination oestrogen and progestagens is responsible for inhibition of ovarian activity, and that there is a delay before the latter respond to stimulation by either endogenous or exogenous gonadotrophins.
作者研究了雌激素 - 孕激素联合用药对促性腺激素分泌及卵巢功能的长期影响。对垂体促黄体生成素（LH）、雌二醇（E2）、孕酮（P）、20α - 羟孕酮（20α - OHP）和睾酮（T）的血浆浓度进行放射免疫水平测定，以此作为本研究的基础。对4名正常志愿者女性进行了一个测试周期以及8个周期的研究，在这8个周期中给予她们50微克乙炔雌二醇和0.5毫克炔诺酮的组合药物。在第7个周期进行了使用50微克促性腺激素“释放因子”（LH - RH）的垂体刺激试验。在3名女性及另外3名受试者的第8个治疗周期中给予人绝经期促性腺激素（HMG）进行卵巢刺激。LH的垂体分泌以及E2和P的卵巢分泌受到部分抑制。垂体对注射LH - RH的反应保持正常，但6名患者中有5名对促性腺激素刺激无反应。这些结果使我们得出结论，雌激素和孕激素联合治疗期间促性腺激素分泌减少是卵巢活动受抑制的原因，并且卵巢对内源性或外源性促性腺激素刺激的反应存在延迟。
