RCAS1表达在食管鳞状细胞癌中的预后意义。

The prognostic significance of RCAS1 expression in squamous cell carcinoma of the oesophagus.

作者信息

Nakakubo Yoshihiro, Hida Yasuhiro, Miyamoto Masaki, Hashida Hideaki, Oshikiri Taro, Kato Kentaro, Suzuoki Masato, Hiraoka Kei, Ito Tomoo, Morikawa Toshiaki, Okushiba Shunichi, Kondo Satoshi, Katoh Hiroyuki

机构信息

Hokkaido University Graduate School of Medicine, Division of Cancer Medicine, Cancer Medicine, Surgical Oncology, N-14, W-5, Sapporo 060-8648, Japan.

出版信息

Cancer Lett. 2002 Mar 8;177(1):101-5. doi: 10.1016/s0304-3835(01)00773-x.

DOI:10.1016/s0304-3835(01)00773-x

PMID:11809537

Abstract

Overexpression of RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) protects cancer cells from immune attack and might be related to poor prognosis in several cancers. We investigated the immunoreactivity of RCAS1 and its correlation with clinicopathological features in 95 patients who underwent surgical resection for oesophageal squamous cell carcinoma. Thirty-two of the 95 (33.7%) cases were strongly positive for RCAS1. RCAS1 showed significant correlations with age and stage grouping. Expression of RCAS1 was associated with shorter postoperative survival. Multivariate analysis indicated that RCAS1 positivity was an independent negative prognostic factor. Our study establishes RCAS1 as a novel prognostic marker for surgically resected oesophageal squamous cell carcinoma.

摘要

RCAS1（SiSo细胞上表达的受体结合癌抗原）的过表达可保护癌细胞免受免疫攻击，并且可能与多种癌症的不良预后相关。我们调查了95例行食管鳞状细胞癌手术切除患者中RCAS1的免疫反应性及其与临床病理特征的相关性。95例患者中有32例（33.7%）RCAS1呈强阳性。RCAS1与年龄和分期分组显著相关。RCAS1的表达与术后生存期较短有关。多因素分析表明，RCAS1阳性是一个独立的阴性预后因素。我们的研究确立了RCAS1作为手术切除食管鳞状细胞癌的一种新的预后标志物。