First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 M. Asias steet, Goudi, GR11527 Athens, Greece ; Department of Food Science and Nutrition, University of the Aegean, Myrina, Lemnos, Greece.
Dis Markers. 2013;35(4):213-9. doi: 10.1155/2013/527548. Epub 2013 Sep 3.
The receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human tumor-associated antigen that has been considered to play a crucial role in tumor progression by enabling cancer cells to evade immune surveillance. The present study aimed to evaluate the clinical significance of the RCAS1 expression in gastric adenocarcinoma.
RCAS1 protein expression was assessed immunohistochemically on 54 gastric adenocarcinoma tissue samples and was analyzed in relation to clinicopathological parameters, tumor proliferative capacity, and patients' survival.
Enhanced RCAS1 expression levels were significantly associated with advanced histopathological stage and presence of organ metastasis (P = 0.0084 and P = 0.0327). Gastric cancer patients with elevated RCAS1 expression levels showed significantly shorter survival times compared to those with low RCAS1 expression (log-rank test, P = 0.0168). In multivariate analysis, histopathological stage and grade of differentiation as well as the RCAS1 expression were identified as independent prognostic factors (Cox regression analysis, P = 0.0204, P = 0.0035, and P = 0.0081).
Our data support the evidence that RCAS1 upregulation may contribute to gastric malignant progression, representing a useful biomarker to predict the biological behaviour and prognosis in gastric neoplasia.
SiSo 细胞表达的受体结合癌抗原（RCAS1）是人肿瘤相关抗原，它被认为通过使癌细胞逃避免疫监视在肿瘤进展中发挥关键作用。本研究旨在评估 RCAS1 在胃腺癌中的表达的临床意义。
采用免疫组织化学方法检测 54 例胃腺癌组织标本中 RCAS1 蛋白的表达，并分析其与临床病理参数、肿瘤增殖能力和患者生存的关系。
增强的 RCAS1 表达水平与晚期组织病理学分期和器官转移显著相关（P=0.0084 和 P=0.0327）。RCAS1 表达水平升高的胃癌患者的生存时间明显短于 RCAS1 表达水平低的患者（对数秩检验，P=0.0168）。多因素分析显示，组织病理学分期和分化程度以及 RCAS1 表达是独立的预后因素（Cox 回归分析，P=0.0204，P=0.0035 和 P=0.0081）。
我们的数据支持 RCAS1 上调可能有助于胃恶性进展的证据，它是预测胃肿瘤生物学行为和预后的有用生物标志物。
