White L J, Schukken Y H, Lam T J, Medley G F, Chappell M J
Department of Biological Sciences, University of Warwick, Coventry, UK.
Epidemiol Infect. 2001 Dec;127(3):567-76. doi: 10.1017/s0950268801006100.
Mastitis in dairy cows is a significant economic and animal welfare issue in the dairy industry. The bacterial pathogens responsible for infection of the mammary gland may be split into two main categories: major and minor pathogens. Infection with major pathogens generally results in clinical illness or strong inflammatory responses and reduced milk yields, whereas minor pathogen infection is usually subclinical. Previous investigations have considered the transmission of these pathogens independently. Experimental evidence has shown cross-protection between species of pathogens. In this study a mathematical model for the coupled transmission of major and minor pathogens along with their interaction via the host was developed in order to consider various methods for controlling the incidence of major pathogen infection. A stability analysis of the model equilibria provides explanations for observed phenomena and previous decoupled modelling results. This multispecies model structure has provided a basis for quantifying the extent of cross-protection between species and assessing possible control strategies against the disease.
奶牛乳腺炎是乳制品行业中一个重大的经济和动物福利问题。导致乳腺感染的细菌病原体可分为两大类：主要病原体和次要病原体。主要病原体感染通常会导致临床疾病或强烈的炎症反应，并降低产奶量，而次要病原体感染通常是亚临床的。以往的研究分别考虑了这些病原体的传播。实验证据表明病原体物种之间存在交叉保护。在本研究中，为了考虑控制主要病原体感染发生率的各种方法，建立了一个主要和次要病原体耦合传播及其通过宿主相互作用的数学模型。对模型平衡点的稳定性分析为观察到的现象和先前的解耦建模结果提供了解释。这种多物种模型结构为量化物种间交叉保护的程度和评估针对该疾病的可能控制策略提供了基础。
