Bonneux L
Department of Public Health, Erasmus University Rotterdam, The Netherlands.
J Epidemiol Community Health. 2002 Feb;56(2):128-31. doi: 10.1136/jech.56.2.128.
To explore various methods to quantify the burden of mortality, with a special interest for the more recent method at the core of calculations of disability adjusted life years (DALY).
Various methods calculating the age schedule at death are applied to two historical life table populations. One method calculates the "years of life lost", by multiplying the numbers of deaths at age x by the residual life expectancy. This residual life expectancy may be discounted and age weighted. The other method calculates the "potential years of life lost" by multiplying the numbers of deaths at age x by the years missing to reach a defined threshold (65 years or 75 years).
The period life tables describing the mortality of Dutch male populations from 1900-10 (high mortality) and from 1990-1994 (low mortality).
A standard life table with idealised long life expectancy increases the burden of death more if mortality is lower. People at old age, more prevalent if mortality is low, lose more life years in an idealised life table. The discounted life table decreases the burden of death strongly if mortality is high: the life lost by a person dying at a young age is discounted. Age weighting the discounted life table balances the effect of discounting.
For the purpose of description of the burden of mortality, the aggregate life table of the studied populations gives the better description of the age schedule at death. Discounting and the use of idealised lifetables as a standard increase the burden of mortality of degenerative disease at the end of life. The age weighted discounted life table violates the principle of parsimony.
探索量化死亡负担的各种方法,尤其关注作为伤残调整生命年(DALY)计算核心的最新方法。
将各种计算死亡年龄分布的方法应用于两个历史生命表人群。一种方法是通过将x岁时的死亡人数乘以剩余预期寿命来计算“生命年损失”。这种剩余预期寿命可以进行贴现和年龄加权。另一种方法是通过将x岁时的死亡人数乘以达到规定阈值(65岁或75岁)所缺少的年数来计算“潜在生命年损失”。
时期生命表描述了1900 - 1910年(高死亡率)和1990 - 1994年(低死亡率)荷兰男性人群的死亡率。
如果死亡率较低,具有理想化长预期寿命的标准生命表会使死亡负担增加更多。在理想化生命表中,老年人(如果死亡率低则更为普遍)损失的生命年更多。如果死亡率高,贴现生命表会大幅降低死亡负担:年轻时死亡的人所损失的生命被贴现。对贴现生命表进行年龄加权可平衡贴现的影响。
为了描述死亡负担,所研究人群的总体生命表能更好地描述死亡年龄分布。贴现以及使用理想化生命表作为标准会增加生命末期退行性疾病的死亡负担。年龄加权贴现生命表违背了简约原则。