Hartz Richard A, Gilligan Paul J, Nanda Kausik K, Tebben Andrew J, Fitzgerald Larry W, Miller Keith
DuPont Pharmaceuticals Company, Chemical and Physical Sciences, Experimental Station, PO Box 80500, 19880, Wilmington, DE 19880, USA.
Bioorg Med Chem Lett. 2002 Feb 11;12(3):291-4. doi: 10.1016/s0960-894x(01)00741-7.
A novel series of imidazo[1,5-a]pyrazines was synthesized and evaluated as corticotropin releasing hormone (CRH) receptor ligands. SAR studies focused primarily on dialkylamino side chain optimization. SAR of the aryl and small alkyl substituents was also explored.
