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通过3-CR/2-CR序列高效合成高度取代的咪唑并[1,5-a]吡嗪衍生物

A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence.

作者信息

Shaabani Ahmad, Maleki Ali, Mofakham Hamid

机构信息

Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, Iran.

出版信息

Mol Divers. 2009 Feb;13(1):63-7. doi: 10.1007/s11030-008-9099-3. Epub 2008 Nov 21.

DOI:10.1007/s11030-008-9099-3
PMID:19023673
Abstract

By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo[1,5-a]pyrazine derivatives.

摘要

通过将2,3-二氨基马来腈、酮和异腈的三组分反应与由基于异腈的三组分反应得到的1,6-二氢吡嗪-2,3-二腈衍生物随后与各种烷基和芳基异氰酸酯或异硫氰酸酯的反应相结合，可以组装出一类新型的高度取代的咪唑并[1,5-a]吡嗪衍生物。

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