7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.
作者信息
Buckley George M, Cooper Nicola, Davenport Richard J, Dyke Hazel J, Galleway Fiona P, Gowers Lewis, Haughan Alan F, Kendall Hannah J, Lowe Christopher, Montana John G, Oxford Janet, Peake Joanna C, Picken C Louise, Richard Marianna D, Sabin Verity, Sharpe Andrew, Warneck Julie B H
机构信息
Celltech R & D, Granta Park, Great Abington, Cambridge CB1 6GS, UK.
出版信息
Bioorg Med Chem Lett. 2002 Feb 11;12(3):509-12. doi: 10.1016/s0960-894x(01)00786-7.
Abstract
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
摘要
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