Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma.

作者信息

Beasley S C, Cooper N, Gowers L, Gregory J P, Haughan A F, Hellewell P G, Macari D, Miotla J, Montana J G, Morgan T, Naylor R, Runcie K A, Tuladhar B, Warneck J B

机构信息

Chiroscience Ltd, Cambridge.

出版信息

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2629-34. doi: 10.1016/s0960-894x(98)00490-9.

DOI:10.1016/s0960-894x(98)00490-9

PMID:9873593

Abstract

The synthesis and pharmacological profile of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described.

摘要

相似文献

1

Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2629-34. doi: 10.1016/s0960-894x(98)00490-9.

2

7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):509-12. doi: 10.1016/s0960-894x(01)00786-7.

3

Aryl sulfonamides as selective PDE4 inhibitors.

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2635-40. doi: 10.1016/s0960-894x(98)00491-0.

4

7-Methoxybenzofuran-4-carboxamides as PDE 4 inhibitors: a potential treatment for asthma.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2137-40. doi: 10.1016/s0960-894x(00)00426-1.

5

Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.9-氨基-4-氧代-1-苯基-3,4,6,7-四氢[1,4]二氮杂卓并[6,7,1-hi]吲哚的合成、构效关系及药理特性：强效、选择性磷酸二酯酶4抑制剂的发现

J Med Chem. 2000 Dec 14;43(25):4850-67. doi: 10.1021/jm000315p.

6

N-arylrolipram derivatives as potent and selective PDE4 inhibitors.

Bioorg Med Chem Lett. 1998 Nov 17;8(22):3229-34. doi: 10.1016/s0960-894x(98)00583-6.

7

8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma.

Bioorg Med Chem Lett. 2002 Jun 17;12(12):1613-5. doi: 10.1016/s0960-894x(02)00223-8.

8

Quaternary substituted PDE IV inhibitors II: the synthesis and in vitro evaluation of a novel series of gamma-lactams.季铵取代的磷酸二酯酶IV抑制剂II：新型γ-内酰胺系列的合成与体外评价

Bioorg Med Chem Lett. 1998 Feb 17;8(4):399-404. doi: 10.1016/s0960-894x(98)00036-5.

9

Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans.

J Med Chem. 1996 Jul 5;39(14):2696-704. doi: 10.1021/jm9509096.

10

Synthesis and biological studies of catechol ether type derivatives as potential phosphodiesterase (PDE) IV inhibitors.

Arch Pharm Res. 1999 Apr;22(2):202-7. doi: 10.1007/BF02976547.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验