Gumbo T, Just-Nübling G, Robertson V, Latif A S, Borok M Z, Hohle R
Department of Medicine, University of Zimbabwe Medical School, Harare, Zimbabwe.
Trans R Soc Trop Med Hyg. 2001 Nov-Dec;95(6):635-6. doi: 10.1016/s0035-9203(01)90103-8.
Reports of disseminated Histoplasma infection in African AIDS patients are scanty. In Zimbabwe, 12 patients presented in 1994-2000 with facial nodular/papular cutaneous lesions, which became umbilicated and finally ulcerated. Histology revealed non-granulomatous inflammation and macrophages stuffed with Histoplasma. Recognition of these clinical features may lead to more rapid diagnosis of disseminated histoplasmosis in Africa.