McBride Troy O, Pogue Brian W, Poplack Steven, Soho Sandra, Wells Wendy A, Jiang Shudong, Osterberg Ulf L, Paulsen Keith D
Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire 03755, USA.
J Biomed Opt. 2002 Jan;7(1):72-9. doi: 10.1117/1.1428290.
Images of hemoglobin concentration and oxygen saturation are presented from multispectral near-infrared tomographic measurements in the breast of a woman with an invasive cancer. Images of the absorption coefficient and reduced scattering coefficient are recovered from the measured data using a finite element reconstruction algorithm based on the frequency-domain diffusion equation. Three methods of recovering the hemoglobin concentration and oxygen saturation images are presented which compensate for water and lipid absorption in different ways: (1) an assumed bulk content of water and lipids is used, (2) four chromophores are imaged, and (3) scattering power data are applied to deduce water and lipid images. In all three cases, a large increase in the hemoglobin concentration (3:1) is observed at the location of the cancer while a maximum of 15% difference is observed in the hemoglobin images between each of these methods for water and lipid compensation.
展示了一名患有浸润性癌症女性乳房的多光谱近红外断层扫描测量中血红蛋白浓度和氧饱和度的图像。基于频域扩散方程，使用有限元重建算法从测量数据中恢复吸收系数和约化散射系数的图像。提出了三种恢复血红蛋白浓度和氧饱和度图像的方法，它们以不同方式补偿水和脂质吸收：（1）使用假定的水和脂质总体含量，（2）对四种发色团成像，（3）应用散射功率数据推导水和脂质图像。在所有三种情况下，在癌症位置观察到血红蛋白浓度大幅增加（3:1），而在这些水和脂质补偿方法中的每一种之间，血红蛋白图像中观察到的最大差异为15%。
