Spinelli Lorenzo, Torricelli Alessandro, Pifferi Antonio, Taroni Paola, Danesini Gian Maria, Cubeddu Rinaldo
INFM, Dipartimento di Fisica and IFN-CNR, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133, Milan, Italy.
J Biomed Opt. 2004 Nov-Dec;9(6):1137-42. doi: 10.1117/1.1803546.
We present the results of a clinical study about optical properties and bulk composition of the female breast. The clinical study involved more than 150 subjects that underwent optical mammography. A multiwavelength time-resolved mammograph designed to collect time-resolved transmittance images of the breast at different wavelengths in the range 637 to 980 nm is used to this purpose. From the absorption spectrum of the breast, the concentrations of the main tissue constituents, i.e., oxygenated and deoxygenated hemoglobin, lipid, and water, are obtained for a subset of 113 breasts. The lipid content of breast is estimated for the first time on such a large number of subjects. The total hemoglobin concentration, blood oxygen saturation, lipid, and water content of breast is correlated to demographic information collected during the trial. As expected, breast optical properties and components undergo huge variations among different subjects. Different constituents, however, show interesting correlation with clinical parameters such as age, breast size, body mass index, and mammographic parenchymal pattern. These results suggest that optical measurements on breasts can be exploited to obtain relevant information on breast tissue composition.
我们展示了一项关于女性乳房光学特性和整体成分的临床研究结果。该临床研究涉及150多名接受光学乳腺造影的受试者。为此使用了一种多波长时间分辨乳腺造影仪，其设计用于收集637至980纳米范围内不同波长下乳房的时间分辨透射率图像。从乳房的吸收光谱中，获得了113个乳房子集的主要组织成分，即氧合血红蛋白、脱氧血红蛋白、脂质和水的浓度。首次在如此大量的受试者中估计了乳房的脂质含量。乳房的总血红蛋白浓度、血氧饱和度、脂质和水含量与试验期间收集的人口统计学信息相关。正如预期的那样，不同受试者之间乳房的光学特性和成分存在巨大差异。然而，不同成分与年龄、乳房大小、体重指数和乳腺实质模式等临床参数显示出有趣的相关性。这些结果表明，对乳房进行光学测量可用于获取有关乳房组织成分的相关信息。
