肝细胞生长因子及其受体在肝癌组织和非肿瘤性肝组织中的基因表达。
Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues.
作者信息
Luo Yun-Quan, Wu Meng-Chao, Cong Wen-Ming
出版信息
World J Gastroenterol. 1999 Apr;5(2):119-121. doi: 10.3748/wjg.v5.i2.119.
AIM
To study the changes of gene expression of hepatocyte growth factor (HGF) and hepatocyte growth factor receptor (HGFr) in hepatocellular carcinoma (HCC) tissue and nontumorous liver tissue and the relationship between these changes and the biological behavior of the tumor.METHODS:Gene expression of HGF and HGFr in 26 cases of HCC tissue and their adjacent nontumorous liver tissues was determined with digoxigenin labeled DNA probes.RESULTS:Positive expression of HGF in HCC tissue was similar to that in the adjacent nontumorous liver tissue, but positive rate of HGF expression was lower than HGFr gene expression. However, HGFr expression was higher in the metastatic cases than in those without metastasis. It was found that HGFr was overexpressed in HCC tissue as well as in the adjacent nontumorous liver tissue.CONCLUSION:There seems to be a close relationship between overexpression of HGFr gene and tumor metastasis, and the HGF and HGFr system plays an important role in regulating tumor growth and metastasis.
目的
研究肝细胞生长因子（HGF）及肝细胞生长因子受体（HGFr）在肝细胞癌（HCC）组织和癌旁肝组织中的基因表达变化，以及这些变化与肿瘤生物学行为之间的关系。方法：采用地高辛标记的DNA探针检测26例HCC组织及其癌旁肝组织中HGF和HGFr的基因表达。结果：HCC组织中HGF的阳性表达与癌旁肝组织相似，但HGF的表达阳性率低于HGFr基因表达。然而，有转移的病例中HGFr表达高于无转移者。发现HGFr在HCC组织及癌旁肝组织中均有过表达。结论：HGFr基因过表达与肿瘤转移似乎密切相关，HGF和HGFr系统在调节肿瘤生长和转移中起重要作用。
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