Bulliard C, Fontana E, Ruiz J
Division d'endocrinologie, diabétologie et du métabolisme, Département de médecine interne, Centre Hospitalier Universitaire Vaudois, Lausanne.
Praxis (Bern 1994). 2001 Dec 20;90(51-52):2266-71.
The incidence of diabetic nephropathy has declined these last decades, but diabetes mellitus still remains the commonest cause of end-stage renal failure, due to an increased prevalence of diabetes mellitus and a longer life expectancy for diabetic patients. The aim of this review is to describe the natural history of diabetic nephropathy and discuss the influence of many factors such as genetic and non-genetic progression promoters, hypertension, hyperglycemia, dyslipidemia, proteinuria and tobacco. Because only a comprehensive treatment strategy of these promoters will reduce the risk of end-stage renal failure, the inclusion of cardiovascular risk factors management and the screening of cardiovascular disease will further contribute to reduce the very high mortality of diabetic patients suffering of diabetic nephropathy.
在过去几十年中，糖尿病肾病的发病率有所下降，但由于糖尿病患病率的上升以及糖尿病患者预期寿命的延长，糖尿病仍然是终末期肾衰竭最常见的病因。本综述的目的是描述糖尿病肾病的自然病程，并讨论多种因素的影响，如遗传和非遗传进展促进因素、高血压、高血糖、血脂异常、蛋白尿和烟草。因为只有对这些促进因素采取全面的治疗策略才能降低终末期肾衰竭的风险，纳入心血管危险因素管理以及筛查心血管疾病将进一步有助于降低患有糖尿病肾病的糖尿病患者的极高死亡率。
