Meier Matthias, Haller Hermann
Medizinische Hochschule Hannover, Hannover, Deutschland.
Herz. 2004 Aug;29(5):496-503. doi: 10.1007/s00059-004-2610-4.
Diabetic nephropathy represents the most important microvascular complication in long-term diabetes mellitus because chronic renal insufficiency is further aggravated by increased cardiovascular morbidity and mortality in diabetic patients. Although early intensive insulin therapy has led to a significant reduction of incidence and prevalence of end-stage renal failure over the last decades in juvenile type 1 diabetes mellitus, the total number of type 2 diabetic patients with chronic renal insufficiency is dramatically increasing due to the improved life expectancy of the general population and the more effective medical treatment of macrovascular complications such as arterial hypertension, coronary artery disease, and peripheral arterial occlusive disease. Apart from the personal burden for each individual the frightening epidemiologic dimension of diabetic nephropathy represents an outstanding challenge for our social systems.
糖尿病肾病是长期糖尿病最重要的微血管并发症，因为糖尿病患者心血管发病率和死亡率增加会进一步加重慢性肾功能不全。尽管在过去几十年中，早期强化胰岛素治疗已使1型青少年糖尿病患者终末期肾衰竭的发病率和患病率显著降低，但由于普通人群预期寿命的延长以及对动脉高血压、冠状动脉疾病和外周动脉闭塞性疾病等大血管并发症更有效的药物治疗，患有慢性肾功能不全的2型糖尿病患者总数正在急剧增加。除了给每个患者带来的个人负担外，糖尿病肾病令人恐惧的流行病学规模对我们的社会体系构成了巨大挑战。
