Hamhaber U, Grieshaber F A, Nagel J, Klose U
Sektion für Experimentelle Kemspinresonanz des ZNS, Abteilung für Neuroradiologie, Eberhard-Karls-Universität Tübingen.
Z Med Phys. 2001;11(4):236-44. doi: 10.1016/s0939-3889(15)70523-4.
Differences of elasticity in tissue phantoms with inclusions of different elasticity were mapped by means of MR elastography (MRE). This new magnetic resonance imaging technique is based on the phase shift of the MR signal by switching a motion sensitizing magnetic field gradient simultaneously with the coupling of a shear wave. Wave patterns showing snapshots of the shear wave that propagates through the investigated substance were depicted in tomographic phase images. It was investigated wether a visualization of differences in elasticity of soft tissues was possible on the basis of differences in the wavelength. For this purpose, tissue phantoms with cylindrical inclusions were produced from agar gels, with agar concentrations between 1.0 and 1.5%. The diameters of the inclusions were of the order of a few centimetres. For diameters as small as 4 cm, there were still distinct differences in the wavelength between the matrix and the inclusion. The results of our study suggest that this technique has the potential for future application as an additional imaging method for tumor detection.
通过磁共振弹性成像(MRE)绘制了包含不同弹性物质的组织模型的弹性差异图。这种新的磁共振成像技术基于在施加剪切波耦合时同时切换运动敏感磁场梯度而引起的磁共振信号的相移。在断层相位图像中描绘了显示通过被研究物质传播的剪切波快照的波形图。研究了基于波长差异是否能够实现软组织弹性差异的可视化。为此,用琼脂凝胶制作了含有圆柱形内含物的组织模型,琼脂浓度在1.0%至1.5%之间。内含物的直径为几厘米量级。对于小至4厘米的直径,基质和内含物之间的波长仍存在明显差异。我们的研究结果表明,这项技术有潜力作为肿瘤检测的一种额外成像方法在未来得到应用。