Synder M, Harcke H T, Conard K, Bowen J R
Orthopedic Clinic Medical University of Lodz, Poland.
Int Orthop. 2001;25(6):337-42. doi: 10.1007/s002640100271.
We performed an experimental epiphysiodesis on the tibia in 16 immature New Zealand white rabbits. The purpose was to study the process of trauma-induced growth plate closure. The animals were killed at weekly intervals over 8 weeks. We correlated the histological findings with serial magnetic resonance images. The undamaged, central part of the growth plate became histologically abnormal within 1 week. Mature bone bridge formation in the area of the epiphysiodesis was seen after 3 to 4 weeks. The study suggests that growth arrest starts before the bone bridge formation. Factors regulating cartilage growth may also play a role.
我们对16只未成年新西兰白兔的胫骨进行了实验性骺骨干固定术。目的是研究创伤诱导生长板闭合的过程。在8周内每隔一周处死动物。我们将组织学结果与系列磁共振成像进行了关联。生长板未受损的中央部分在1周内组织学上就出现了异常。在3至4周后可见骺骨干固定区域形成成熟骨桥。该研究表明生长停滞在骨桥形成之前就已开始。调节软骨生长的因素可能也起作用。
