Joussen A M
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Germany.
Graefes Arch Clin Exp Ophthalmol. 2001 Dec;239(12):972-5. doi: 10.1007/s004170100365.
Most of the blinding diseases, such as diabetic retinopathy, age-related macular degeneration, neovascular glaucoma or trachoma, are related to an aberrant angiogenic response. Common pathological features are ischaemia and increased vascular permeability, in turn leading to neovascularization or atrophy. Recent effort has led to the identification of several factors, such as the angiopoietin-Tie system, which are operative in the control of vasculogenesis and angiogenesis. The aim of this commentary is to summarize briefly the current knowledge about molecular mechanisms involved in the regulation of vascular integrity with special emphasis on the angiopoietins.
大多数致盲性疾病，如糖尿病视网膜病变、年龄相关性黄斑变性、新生血管性青光眼或沙眼，都与异常的血管生成反应有关。常见的病理特征是缺血和血管通透性增加，进而导致新生血管形成或萎缩。最近的研究已鉴定出几种在血管发生和血管生成控制中起作用的因子，如血管生成素-Tie系统。本述评的目的是简要总结目前关于血管完整性调节中涉及的分子机制的知识，特别强调血管生成素。
