Ward Nicole L, Dumont Daniel J
Division of Molecular and Cellular Biology Research, Sunnybrook and Women's College Research Institute, Toronto, Ontario, Canada M4N 3M5.
Semin Cell Dev Biol. 2002 Feb;13(1):19-27. doi: 10.1006/scdb.2001.0288.
The expansion or remodelling of pre-existing blood vessels, known as angiogenesis, by either nascent sprouting, intercalated or intussusceptive growth is a highly regulated process. Angiogenesis is critical not only during normal embryonic vascular development, but also in the progression of several diseases, including cancer, psoriasis, and diabetes. Mouse molecular genetic experiments have shown that the angiopoietins and their receptor Tie2/Tek are indispensable for embryonic vessel development. The importance of the angiopoietin-signalling pathway has also been shown to extend beyond development, into in vitro and in vivo experimental models of angiogenic growth. Currently the precise role of the angiopoietins remains unclear. However, what is emerging from genetic, xenograft transplant, histochemical and cell culture experiments are that the response of endothelial cells to angiopoietins appears to be context and endothelial cell type specific.
通过新生芽生、插入或套叠生长对已存在血管进行的扩张或重塑，即血管生成，是一个高度受调控的过程。血管生成不仅在正常胚胎血管发育过程中至关重要，在包括癌症、银屑病和糖尿病在内的多种疾病进展中也起着关键作用。小鼠分子遗传学实验表明，血管生成素及其受体Tie2/Tek对胚胎血管发育不可或缺。血管生成素信号通路的重要性还体现在其作用范围不仅限于发育阶段，还延伸到血管生成生长的体外和体内实验模型中。目前，血管生成素的确切作用仍不清楚。然而，从基因、异种移植、组织化学和细胞培养实验中逐渐显现的是，内皮细胞对血管生成素的反应似乎具有背景和内皮细胞类型特异性。
