Howie P W, Prentice C R, Forbes C D
Br J Obstet Gynaecol. 1975 Sep;82(9):711-7. doi: 10.1111/j.1471-0528.1975.tb00711.x.
In view of the association between pre-eclampsia and disseminated intravascular coagulation, three patients presenting with severe pre-eclampsia before the 28th week of pregnancy were treated with heparin. In all three patients, there was deterioration of hypertension and proteinuria that necessitated the withdrawal of treatment after five to six days. During treatment, serum and urinary fibrinolytic degradation products (FDPs) continued to rise or remained unaltered, plasminogen levels showed a steady fall, and the platelet count remained at a reduced level. These data suggest that heparin was an ineffective form of treatment and did not prevent the intravascular fibrin deposition associated with severe pre-eclampsia.
鉴于子痫前期与弥散性血管内凝血之间的关联，对3例在妊娠28周前出现严重子痫前期的患者使用肝素进行治疗。在所有3例患者中，均出现高血压和蛋白尿加重的情况，以至于在五到六天后不得不停止治疗。治疗期间，血清和尿中纤维蛋白溶解降解产物（FDPs）持续升高或保持不变，纤溶酶原水平呈稳步下降，血小板计数维持在较低水平。这些数据表明，肝素是一种无效的治疗方式，不能预防与严重子痫前期相关的血管内纤维蛋白沉积。
