Howie P W, Begg C B, Purdie D W, Prentice C R
Lancet. 1976 Aug 14;2(7981):323-5. doi: 10.1016/s0140-6736(76)92587-3.
The clinical manifestations of severe pre-eclampsia are normally separated from those of mild pre-eclampsia and normal pregnancy on arbitrary grounds. A clinical index, based on the increase in diastolic blood-pressure and the presence of proteinuria, was developed to reflect the spectrum of disease from mild to severe pre-eclampsia. This was related to a coagulation index based on the platelet-count, plasma-factor-VIII, and serum-fibrinolytic-degradation-products. The two indices were shown to be strongly correlated. All cases of perinatal death associated with pre-eclampsia had coagulation indices in the most severely abnormal range. These results suggest that intravascular coagulation is a highly characteristic feature of pre-eclampsia and that the coagulation index may be of value in monitoring the progress of the disease.
重度子痫前期的临床表现通常是基于主观标准与轻度子痫前期及正常妊娠的表现相区分。基于舒张压升高和蛋白尿的存在制定了一个临床指标，以反映从轻度到重度子痫前期的疾病谱。这一临床指标与基于血小板计数、血浆因子VIII和血清纤维蛋白溶解降解产物的凝血指标相关。结果显示这两个指标密切相关。所有与子痫前期相关的围产期死亡病例，其凝血指标都处于最严重异常的范围内。这些结果表明，血管内凝血是子痫前期的一个高度特征性表现，并且凝血指标可能在监测该疾病的进展方面具有价值。
