人类成肌细胞分化：钾离子通道激活钙离子通道。
Human myoblast differentiation: Ca(2+) channels are activated by K(+) channels.
作者信息
Bernheim Laurent, Bader Charles R
机构信息
Département de Physiologie, Centre Médical Universitaire, Hôpital Cantonal Universitaire, CH-1211 Geneva 4, Switzerland.
出版信息
News Physiol Sci. 2002 Feb;17:22-6.
PMID:11821532
Abstract
In a paradigm of cellular differentiation, human myoblast fusion, we investigated how a Ca(2+) influx, indispensable for fusion, is triggered. We show how newly expressed Kir2.1 K(+) channels, via their hyperpolarizing effect on the membrane potential, generate a window Ca(2+) current (mediated by alpha 1H T-type Ca(2+) channels), which causes intracellular Ca(2+) to rise.
摘要
在细胞分化的范例——人类成肌细胞融合过程中，我们研究了融合所必需的Ca(2+)内流是如何被触发的。我们展示了新表达的Kir2.1 K(+)通道如何通过其对膜电位的超极化作用，产生一种窗口Ca(2+)电流（由α1H T型Ca(2+)通道介导），从而导致细胞内Ca(2+)升高。
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