Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Department of Biomedical Sciences and Clinical Oncology Oncogenomic Research Center, 'Aldo Moro' University of Bari, 70124 Bari, Italy.
Int J Mol Sci. 2018 Mar 10;19(3):802. doi: 10.3390/ijms19030802.
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD.
糖尿病是心血管疾病的最强危险因素之一，特别是缺血性心脏病 (IHD)。糖尿病患者心肌缺血的病理生理学较为复杂，尚未完全清楚：部分糖尿病患者主要存在冠状动脉狭窄，阻碍了心肌的血液供应；而另一些患者则存在冠状动脉微血管疾病，心外膜血管无斑块。在心肌能量状态与冠状动脉血流之间相互作用的离子通道可能在糖尿病患者的 IHD 病理生理学中发挥作用。具体来说，一些与三磷酸腺苷 (ATP) 依赖性钾通道相关的遗传变异似乎与 IHD 的发生有关。
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