Fennelly Colin, Soker Shay
Department of Neuroscience, Novartis Institutes for BioMedical Research, Inc., Cambridge, Massachusetts.
Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina.
Bioelectricity. 2019 Mar 1;1(1):35-45. doi: 10.1089/bioe.2018.0002. Epub 2019 Mar 18.
Modern stem cell research has mainly focused on protein expression and transcriptional networks. However, transmembrane voltage gradients generated by ion channels and transporters have demonstrated to be powerful regulators of cellular processes. These physiological cues exert influence on cell behaviors ranging from differentiation and proliferation to migration and polarity. Bioelectric signaling is a fundamental element of living systems and an untapped reservoir for new discoveries. Dissecting these mechanisms will allow for novel methods of controlling cell fate and open up new opportunities in biomedicine. This review focuses on the role of ion channels and the resting membrane potential in the proliferation and differentiation of skeletal muscle progenitor cells. In addition, findings relevant to this topic are presented and potential implications for tissue engineering and regenerative medicine are discussed.
现代干细胞研究主要集中在蛋白质表达和转录网络上。然而，离子通道和转运体产生的跨膜电压梯度已被证明是细胞过程的强大调节因子。这些生理信号对细胞行为产生影响，范围从分化、增殖到迁移和极性。生物电信号是生命系统的基本要素，也是尚未开发的新发现宝库。剖析这些机制将带来控制细胞命运的新方法，并为生物医学开辟新机遇。本综述重点关注离子通道和静息膜电位在骨骼肌祖细胞增殖和分化中的作用。此外，还介绍了与该主题相关的研究结果，并讨论了其对组织工程和再生医学的潜在影响。
