Fisseler-Eckhoff A
Institut für Pathologie, Zentralklinik Emil-von-Behring, Gimpelsteig 3-9, 14165 Berlin.
Kongressbd Dtsch Ges Chir Kongr. 2001;118:590-5.
Histological typing of lung tumors is based on the new WHO-IASLC classification of lung and pleural tumors published in 1999. Based on histological growth pattern, the major light microscopic categories of lung carcinomas are squamous cell carcinoma, small cell carcinoma, adenocarcinoma and large cell carcinoma. The further subclassification within the main categories resembles the high degree of lung tumor heterogeneity. Immunohistochemistry may detect differentiation that cannot be seen by routine light microscopy on small bioptically obtained specimens. Evaluation of the proliferation index of tumor cells, hormonal receptors, oncogenes and tumor-suppressor genes is possible. Oncogenes, tumor-suppressor genes, angiogenetical factors as well as single cell dissemination of tumor cells in lymph nodes are discussed as possible prognostic factors.
肺肿瘤的组织学分类基于1999年出版的世界卫生组织-国际肺癌研究协会（WHO-IASLC）关于肺和胸膜肿瘤的新分类。根据组织学生长模式，肺癌的主要光镜类别为鳞状细胞癌、小细胞癌、腺癌和大细胞癌。主要类别内的进一步细分反映了肺肿瘤高度的异质性。免疫组织化学可检测在小活检标本上常规光镜无法观察到的分化情况。评估肿瘤细胞的增殖指数、激素受体、癌基因和肿瘤抑制基因是可行的。癌基因、肿瘤抑制基因、血管生成因子以及肿瘤细胞在淋巴结中的单细胞播散被作为可能的预后因素进行讨论。
