Xiao Desheng, Jia Jiantao, Shi Ying, Fu Chunyan, Chen Ling, Jiang Yiqun, Zhou Li, Liu Shuang, Tao Yongguang
Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, China.
Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China.
Oncotarget. 2015 Sep 22;6(28):25499-505. doi: 10.18632/oncotarget.4548.
The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlated with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer.
IKKα在体内的功能作用相当复杂，这很大程度上归因于其通过细胞自主和非自主方式发挥的多种功能。此外，大多数关于IKKα的研究都来自动物模型，这些发现在人类肿瘤中是否成立仍不清楚。在这里，我们检测了IKKα在鼻咽癌（包括非角化癌和角化鳞状细胞癌）以及有角化和无角化的肺鳞状细胞癌中的表达。我们证明，IKKα在角化癌中表达几乎为阴性，而在非角化癌中发现IKKα表达较高，并且IKKα表达与非角化鼻咽癌肿瘤的细胞分化相关。这些发现表明，IKKα在同一类型癌症的角化和非角化癌中表达存在差异。
