Allica E, Serke M, Loddenkemper R, Kaiser D
Zentralklinik Emil von Behring, Department Lungenklinik Heckeshorn, Zum Heckeshorn 33, 14109 Berlin.
Kongressbd Dtsch Ges Chir Kongr. 2001;118:596-600.
We analysed our results of multimodal therapy including chemotherapy, radiotherapy and surgery in 150 consecutive patients with SCLC stage I-IIIa operated on in our hospital between 1983 and 2000. Median age: 58 years, stages see Table 2. Patients with proven SCLC had induction chemotherapy prior to surgery. All patients received three cycles of adjuvant chemotherapy, some with additional radiotherapy. Perioperative mortality: 2%. Median survival: 22.4 months. R0 resection was possible in 84% of all patients. Pre- and post-surgery staging differed in the majority of the patients. Rotes of 1-, 2- and 5-year survival were 79%, 47%, and 32%, respectively. A median survival of 22.4 months in multimodally treated LD-SCLC, most of them stage IIb/IIIa appears promising. Randomized studies based on clinical staging procedures are not recommended. Survival data are promising.
我们分析了1983年至2000年间在我院接受手术的150例连续的I-IIIa期小细胞肺癌患者的多模式治疗结果,包括化疗、放疗和手术。中位年龄:58岁,分期见表2。确诊为小细胞肺癌的患者在手术前接受诱导化疗。所有患者均接受三个周期的辅助化疗,部分患者还接受了额外的放疗。围手术期死亡率:2%。中位生存期:22.4个月。84%的患者能够实现R0切除。大多数患者术前和术后分期不同。1年、2年和5年生存率分别为79%、47%和32%。多模式治疗的局限期小细胞肺癌患者的中位生存期为22.4个月,其中大多数为IIb/IIIa期,这似乎很有前景。不建议进行基于临床分期程序的随机研究。生存数据很有前景。