Hanna J N, Young D M, Brookes D L, Dostie B G, Murphy D M
Tropical Public Health Unit, Queensland Health, Cairns.
Aust N Z J Public Health. 2001 Dec;25(6):543-6. doi: 10.1111/j.1467-842x.2001.tb00321.x.
To describe the initial coverage and impact of a pneumococcal and influenza vaccination program for at-risk Indigenous adults in Far North Queensland that formally commenced in 1996.
Ascertainment of vaccine coverages, and prospective laboratory surveillance of invasive pneumococcal disease occurring in Indigenous adults in the region.
Coverages of the first doses of both vaccines administered since 1995, and the incidence of invasive pneumococcal disease in Indigenous adults in the region between 1993-2000.
Most (96% and 73%) of the Indigenous adults > or = 50 years of age received influenza and pneumococcal vaccines, respectively, for the first time between 1995-2000. Assuming that either 33% or 50% of Indigenous adults 15-49 years of age in Far North Queensland were eligible for vaccination, then either 109% or 72% of this population received influenza vaccine, and either 75% or 50% received pneumococcal vaccine, respectively, for the first time between 1995-2000. The incidence of vaccine-preventable invasive pneumococcal disease fell from 111 (95% confidence interval [CI] 77-154) cases per 100,000 per year in 1993/94 to 28 (95% CI 13-53) cases per 100,000 per year in 1999-2000 (p<0.05).
Although there was a significant decline in the incidence of invasive pneumococcal disease, the vaccine coverages after five years of the program were suboptimal. Because of the difficulties in targeting the 15-49 years age group and because of unrecognised risk factors, we suggest that a universal Indigenous adult pneumococcal and influenza vaccination program should be considered.
描述1996年正式启动的针对昆士兰远北地区高危原住民成年人的肺炎球菌和流感疫苗接种计划的初始覆盖率及影响。
确定疫苗覆盖率,并对该地区原住民成年人中发生的侵袭性肺炎球菌病进行前瞻性实验室监测。
1995年以来两种疫苗首剂的接种率,以及1993 - 2000年该地区原住民成年人侵袭性肺炎球菌病的发病率。
1995 - 2000年间,大多数(分别为96%和73%)50岁及以上的原住民成年人首次接种了流感疫苗和肺炎球菌疫苗。假设昆士兰远北地区15 - 49岁的原住民成年人中有33%或50%符合接种条件,那么在1995 - 2000年间,该年龄段人群分别有109%或72%首次接种了流感疫苗,分别有75%或50%首次接种了肺炎球菌疫苗。可通过疫苗预防的侵袭性肺炎球菌病发病率从1993/94年的每年每10万人111例(95%置信区间[CI] 77 - 154)降至1999 - 2000年的每年每10万人28例(95% CI 13 - 53)(p<0.05)。
尽管侵袭性肺炎球菌病发病率显著下降,但该计划实施五年后的疫苗覆盖率仍未达到最佳水平。鉴于确定15 - 49岁年龄组的困难以及存在未被认识的风险因素,我们建议应考虑开展全民原住民成年人肺炎球菌和流感疫苗接种计划。