Onaga Takenori, Zabielski Romuald, Kato Seiyu
School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
Peptides. 2002 Feb;23(2):279-90. doi: 10.1016/s0196-9781(01)00609-x.
In the last two decades, multiple aspects of the peptide YY (PYY) secretion have been investigated. Besides fat and fatty acids, many luminal nutrients in the distal intestine appear to induce PYY release. Some studies have shown that bile acid, but not nutrients, plays a crucial role in the regulation of PYY secretion. Moreover, chyme in the proximal intestine also regulates the peptide release by indirect action through humoral and neuronal factors. Gastrin, cholecystokinin, and the vagus nerve are major candidates for mediators of these indirect actions. Several growth factors have been shown to regulate PYY synthesis in mucosa of the distal intestine. This review is aimed at presenting an overview of these recent studies on PYY secretion in the distal intestine.
在过去二十年中，人们对肽YY（PYY）分泌的多个方面进行了研究。除脂肪和脂肪酸外，远端肠道中的许多腔内营养物质似乎也能诱导PYY释放。一些研究表明，胆汁酸而非营养物质在PYY分泌的调节中起关键作用。此外，近端肠道中的食糜也通过体液和神经因子的间接作用来调节肽的释放。胃泌素、胆囊收缩素和迷走神经是这些间接作用的主要介导物候选者。已有研究表明，几种生长因子可调节远端肠道黏膜中PYY的合成。本综述旨在概述这些关于远端肠道中PYY分泌的最新研究。
