Liu Menglin, Fan Genhao, Meng Lingkai, Yang Kuo, Liu Huayi
The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Brain Disease Regional Diagnosis and Treatment Center, Zhengzhou 450000, China.
Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China.
J Zhejiang Univ Sci B. 2025 Jan 15;26(1):1-25. doi: 10.1631/jzus.B2300343. Epub 2024 Sep 27.
Patients with depression are more likely to have chronic gastrointestinal (GI) symptoms than the general population, but such symptoms are considered only somatic symptoms of depression and lack special attention. There is a chronic lack of appropriate diagnosis and effective treatment for patients with depression accompanied by GI symptoms, and studying the association between depression and GI disorders (GIDs) is extremely important for clinical management. There is growing evidence that depression is closely related to the microbiota present in the GI tract, and the microbiota-gut-brain axis (MGBA) is creating a new perspective on the association between depression and GIDs. Identifying and treating GIDs would provide a key opportunity to prevent episodes of depression and may also improve the outcome of refractory depression. Current studies on depression and the microbially related gut-brain axis (GBA) lack a focus on GI function. In this review, we combine preclinical and clinical evidence to summarize the roles of the microbially regulated GBA in emotions and GI function, and summarize potential therapeutic strategies to provide a reference for the study of the pathomechanism and treatment of depression in combination with GI symptoms.
与普通人群相比，抑郁症患者更易出现慢性胃肠道（GI）症状，但此类症状仅被视为抑郁症的躯体症状，未得到特别关注。对于伴有GI症状的抑郁症患者，长期缺乏恰当的诊断和有效的治疗，因此研究抑郁症与胃肠道疾病（GIDs）之间的关联对临床管理极为重要。越来越多的证据表明，抑郁症与胃肠道中存在的微生物群密切相关，微生物-肠道-脑轴（MGBA）为抑郁症与GIDs之间的关联提供了新视角。识别并治疗GIDs将为预防抑郁症发作提供关键契机，还可能改善难治性抑郁症的治疗效果。目前关于抑郁症及微生物相关肠-脑轴（GBA）的研究缺乏对GI功能的关注。在本综述中，我们结合临床前和临床证据，总结微生物调节的GBA在情绪和GI功能中的作用，并总结潜在的治疗策略，为结合GI症状研究抑郁症的发病机制和治疗提供参考。
