Kuroda N, Sugimoto T, Numoto S, Enzan H
First Department of Pathology, Kochi Medical School, Kohasu, Oko-cho, Nankoku City, Kochi 783-8505, Japan.
J Clin Pathol. 2002 Jan;55(1):76-7. doi: 10.1136/jcp.55.1.76.
A 53 year old woman presented with a lump in the inner lower quadrant of the left breast. Histological examination of the breast tumour confirmed that the lesion was a mammary hamartoma. Carcinoma with foci of microinvasion was observed in the lobules of the hamartoma concomitant with the intraductal spread of lobular carcinoma. Immunohistochemically, the cancer cells were negative for beta-catenin, which generally stained normal breast ducts and ductal carcinomas. This is only the sixth case of breast carcinoma arising in a mammary hamartoma to be reported and, moreover, the fourth case of lobular carcinoma occurring within a hamartoma. Despite the apparent rarity of this case, pathologists should be aware of the possibility of carcinomas arising within mammary hamartomas.
一名53岁女性因左乳内下象限出现肿块前来就诊。对乳腺肿瘤进行组织学检查证实该病变为乳腺错构瘤。在错构瘤的小叶中观察到伴有小叶癌导管内播散的微浸润灶癌。免疫组化显示，癌细胞β-连环蛋白染色阴性，而β-连环蛋白通常在正常乳腺导管和导管癌中呈阳性染色。这是有报道的第六例发生于乳腺错构瘤内的乳腺癌病例，此外，也是第四例发生于错构瘤内的小叶癌病例。尽管该病例明显罕见，但病理学家应意识到乳腺错构瘤内发生癌变的可能性。
