Arthan Damrongkiet, Svasti Jisnuson, Kittakoop Prasat, Pittayakhachonwut Daraporn, Tanticharoen Morakot, Thebtaranonth Yodhathai
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Phytochemistry. 2002 Feb;59(4):459-63. doi: 10.1016/s0031-9422(01)00417-4.
The C-4 sulfated isoflavonoid, torvanol A (1), and the steroidal glycoside, torvoside H (3), together with the known glycoside, torvoside A (2), were isolated from a MeOH extract of Solanum torvum fruits. Upon enzymatic hydrolysis with beta-glucosidase, torvoside A (2) and torvoside H (3) yielded the corresponding acetal derivatives 4 and 5, respectively. Torvanol A (1), torvoside H (3) and compound 5 exhibited antiviral activity (herpes simplex virus type 1) with IC(50) values of 9.6, 23.2 and 17.4 microg/ml, respectively. Compounds 1-5 showed no cytotoxicity (at 50 microg/ml) against BC, KB and Vero cell lines.
从刺天茄果实的甲醇提取物中分离出C-4硫酸化异黄酮类化合物托瓦诺醇A（1）、甾体糖苷托沃苷H（3）以及已知糖苷托沃苷A（2）。用β-葡萄糖苷酶进行酶水解后，托沃苷A（2）和托沃苷H（3）分别生成相应的缩醛衍生物4和5。托瓦诺醇A（1）、托沃苷H（3）和化合物5表现出抗病毒活性（针对1型单纯疱疹病毒），IC50值分别为9.6、23.2和17.4微克/毫升。化合物1 - 5对BC、KB和Vero细胞系无细胞毒性（在50微克/毫升时）。
