多次输血患者血清中补体依赖和细胞依赖的抗血小板体液抗体。
Complement-dependent and cell-dependent antiplatelet humoral antibody in sera from multi-transfused patients.
作者信息
Macdonald J S, Wunderlich J R, Yust I, Yankee R A
出版信息
Clin Exp Immunol. 1975 Aug;21(2):259-66.
Sera from eight multi-transfused patients, who were resistant to platelet trans-fusions from allogeneic donors, were tested for antiplatelet humoral antibody. Complement-dependent cytotoxic humoral antibody against platelets was found in sera from six of eight patients. Cell-dependent cytotoxic humoral antibody against platelets was found in sera from four of seven of these patients. Sera from two patients had cell-dependent antiplatelet activity but no detectable complement-dependent antiplatelet activity. Results of this study argue that both complement-dependent and cell-dependent humoral immunity may be important pathways for in vivo resistance to platelets.
对8名多次输血且对来自异体供者的血小板输注产生抵抗的患者的血清进行抗血小板体液抗体检测。在8名患者中的6名患者的血清中发现了补体依赖的细胞毒性抗血小板体液抗体。在其中7名患者中的4名患者的血清中发现了细胞依赖的细胞毒性抗血小板体液抗体。2名患者的血清具有细胞依赖的抗血小板活性，但未检测到补体依赖的抗血小板活性。本研究结果表明，补体依赖和细胞依赖的体液免疫可能都是体内对血小板产生抵抗的重要途径。
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