口服感染鼠伤寒沙门氏菌的悉生仔猪体内的一氧化氮代谢产物
Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar typhimurium.
作者信息
Trebichavský I, Zídek Z, Franková D, Zahradnícková M, Splíchal I
机构信息
Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 549 22 Nový Hrádek, Czechia.
出版信息
Folia Microbiol (Praha). 2001;46(4):353-8. doi: 10.1007/BF02815626.
Reactive NO metabolites play a distinct role in the control of Salmonella enterica serovar Typhimurium (ST; a facultative intracellular pathogen) in susceptible host. A significant increase of nitrite and/or nitrate plasma levels, 3-nitro-tyrosine expression and pathological changes in mesenteric lymph nodes have been observed in gnotobiotic piglets orally infected for 1 d with a virulent strain of ST but not in piglets infected with a rough mutant of ST.
反应性一氧化氮代谢产物在易感宿主对肠炎沙门氏菌鼠伤寒血清型（ST；一种兼性细胞内病原体）的控制中发挥着独特作用。在用毒力强的ST菌株口服感染1天的悉生仔猪中，观察到血浆中亚硝酸盐和/或硝酸盐水平显著升高、3-硝基酪氨酸表达以及肠系膜淋巴结出现病理变化，但在感染ST粗糙突变株的仔猪中未观察到这些现象。
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