早幼粒细胞白血病蛋白（PML）在肿瘤抑制中的作用。
The role of PML in tumor suppression.
作者信息
Salomoni Paolo, Pandolfi Pier Paolo
机构信息
Molecular Biology Program and Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
出版信息
Cell. 2002 Jan 25;108(2):165-70. doi: 10.1016/s0092-8674(02)00626-8.
Abstract
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
摘要
PML基因参与急性早幼粒细胞白血病（APL）的t(15;17)染色体易位，编码一种定位于PML核体（一种亚核大分子结构）的蛋白质。PML控制细胞凋亡、细胞增殖和衰老。在此，我们综述目前对其在肿瘤抑制中作用的认识。
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