Buzsáki György
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA.
Neuron. 2002 Jan 31;33(3):325-40. doi: 10.1016/s0896-6273(02)00586-x.
Theta oscillations represent the "on-line" state of the hippocampus. The extracellular currents underlying theta waves are generated mainly by the entorhinal input, CA3 (Schaffer) collaterals, and voltage-dependent Ca(2+) currents in pyramidal cell dendrites. The rhythm is believed to be critical for temporal coding/decoding of active neuronal ensembles and the modification of synaptic weights. Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research.
θ振荡代表海马体的“在线”状态。θ波背后的细胞外电流主要由内嗅输入、CA3(谢弗)侧支以及锥体细胞树突中的电压依赖性Ca(2+)电流产生。这种节律被认为对于活跃神经元群的时间编码/解码以及突触权重的改变至关重要。然而,关于θ振荡的产生及其功能意义的众多关键问题仍然是未来研究的挑战。