• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

海马体中的θ振荡。

Theta oscillations in the hippocampus.

作者信息

Buzsáki György

机构信息

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA.

出版信息

Neuron. 2002 Jan 31;33(3):325-40. doi: 10.1016/s0896-6273(02)00586-x.

DOI:10.1016/s0896-6273(02)00586-x
PMID:11832222
Abstract

Theta oscillations represent the "on-line" state of the hippocampus. The extracellular currents underlying theta waves are generated mainly by the entorhinal input, CA3 (Schaffer) collaterals, and voltage-dependent Ca(2+) currents in pyramidal cell dendrites. The rhythm is believed to be critical for temporal coding/decoding of active neuronal ensembles and the modification of synaptic weights. Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research.

摘要

θ振荡代表海马体的“在线”状态。θ波背后的细胞外电流主要由内嗅输入、CA3(谢弗)侧支以及锥体细胞树突中的电压依赖性Ca(2+)电流产生。这种节律被认为对于活跃神经元群的时间编码/解码以及突触权重的改变至关重要。然而,关于θ振荡的产生及其功能意义的众多关键问题仍然是未来研究的挑战。

相似文献

1
Theta oscillations in the hippocampus.海马体中的θ振荡。
Neuron. 2002 Jan 31;33(3):325-40. doi: 10.1016/s0896-6273(02)00586-x.
2
Long-term plasticity is proportional to theta-activity.长期可塑性与θ波活动成正比。
PLoS One. 2009 Jun 9;4(6):e5850. doi: 10.1371/journal.pone.0005850.
3
Hippocampus and Entorhinal Cortex Recruit Cholinergic and NMDA Receptors Separately to Generate Hippocampal Theta Oscillations.海马体和内嗅皮层分别募集胆碱能和 NMDA 受体以产生海马体θ振荡。
Cell Rep. 2017 Dec 19;21(12):3585-3595. doi: 10.1016/j.celrep.2017.11.080.
4
Nicotine induction of theta frequency oscillations in rodent hippocampus in vitro.尼古丁诱导的体外啮齿动物海马体θ频率振荡。
Neuroscience. 2010 Mar 10;166(1):84-93. doi: 10.1016/j.neuroscience.2009.11.072. Epub 2009 Dec 23.
5
Interdependence of multiple theta generators in the hippocampus: a partial coherence analysis.海马体中多个θ波发生器的相互依赖性:偏相干分析
J Neurosci. 1999 Jul 15;19(14):6200-12. doi: 10.1523/JNEUROSCI.19-14-06200.1999.
6
A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus.一项关于海马体CA1锥体细胞上谢弗侧支突触θ周期期间可塑性的计算研究。
Hippocampus. 2015 Feb;25(2):208-18. doi: 10.1002/hipo.22365. Epub 2014 Sep 25.
7
Distinct gamma oscillations in the distal dendritic fields of the dentate gyrus and the CA1 area of mouse hippocampus.在小鼠海马齿状回的远端树突场和 CA1 区存在明显的γ振荡。
Brain Struct Funct. 2017 Sep;222(7):3355-3365. doi: 10.1007/s00429-017-1421-3. Epub 2017 Apr 8.
8
NMDA receptor-dependent plasticity of granule cell spiking in the dentate gyrus of normal and epileptic rats.正常和癫痫大鼠齿状回颗粒细胞放电中NMDA受体依赖性可塑性
J Neurophysiol. 2000 Dec;84(6):2868-79. doi: 10.1152/jn.2000.84.6.2868.
9
GABAergic contributions to gating, timing, and phase precession of hippocampal neuronal activity during theta oscillations.在θ振荡期间,GABA 能神经元活动的门控、定时和相位超前对海马神经元活动的贡献。
Hippocampus. 2012 Jul;22(7):1597-621. doi: 10.1002/hipo.21002. Epub 2012 Jan 18.
10
GABAergic modulation of hippocampal population activity: sequence learning, place field development, and the phase precession effect.海马体群体活动的γ-氨基丁酸能调制:序列学习、位置野发育及相位进动效应
J Neurophysiol. 1997 Jul;78(1):393-408. doi: 10.1152/jn.1997.78.1.393.

引用本文的文献

1
Theta rhythm as a real-time quantitative marker for non-invasive analysis of adult neurogenesis in the intact brain.θ节律作为完整大脑中成年神经发生无创分析的实时定量标志物。
J Biol Methods. 2025 May 2;12(3):e99010061. doi: 10.14440/jbm.2024.0133. eCollection 2025.
2
Resting-state EEG associated with clinical measures to predict upper limb motor recovery of subacute stroke.静息态脑电图与临床指标相关联以预测亚急性中风患者上肢运动恢复情况。
Front Neurol. 2025 Aug 22;16:1577393. doi: 10.3389/fneur.2025.1577393. eCollection 2025.
3
Cannabidiol dampens propagation of hippocampal hyperactivity and differentially modulates feedforward and feedback inhibition.
大麻二酚可抑制海马体过度活跃的传播,并对前馈抑制和反馈抑制进行不同程度的调节。
bioRxiv. 2025 Aug 26:2025.08.26.672420. doi: 10.1101/2025.08.26.672420.
4
Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer's disease.在阿尔茨海默病的5xFAD模型中,恐惧条件反射期间锥体层和海马槽中的钙动力学和电生理活动受到破坏。
Front Aging Neurosci. 2025 Aug 20;17:1550673. doi: 10.3389/fnagi.2025.1550673. eCollection 2025.
5
Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells.他源性和自身性空间线索控制位置细胞的多重θ相位编码。
Nat Neurosci. 2025 Aug 26. doi: 10.1038/s41593-025-02038-6.
6
Serotonin Modulation of Dorsoventral Hippocampus in Physiology and Schizophrenia.5-羟色胺对生理和精神分裂症中背腹侧海马体的调节作用
Int J Mol Sci. 2025 Jul 27;26(15):7253. doi: 10.3390/ijms26157253.
7
Theta-phase locking of single neurons during human spatial memory.人类空间记忆过程中单个神经元的θ相位锁定
Nat Commun. 2025 Aug 11;16(1):7402. doi: 10.1038/s41467-025-62553-9.
8
Acute EtOH enhances septohippocampal coordination but disrupts intrinsic hippocampal theta dynamics during foraging.急性乙醇增强觅食过程中隔海马协调,但破坏海马固有θ节律动力学。
bioRxiv. 2025 Jul 26:2025.07.22.666144. doi: 10.1101/2025.07.22.666144.
9
From Gamma Coherence to Theta-Phase Synchronization: Task-Dependent Interhemispheric Integration in Boundary-Free Multiple-Object Tracking.从伽马相干到theta相位同步:无边界多目标跟踪中任务依赖的半球间整合
Brain Sci. 2025 Jul 4;15(7):722. doi: 10.3390/brainsci15070722.
10
Altered patterning of neural activity in a neuropathology.神经病理学中神经活动模式的改变。
Sci Rep. 2025 Jul 16;15(1):25881. doi: 10.1038/s41598-025-08538-6.