[Bay K8644和硝苯地平对大鼠下丘脑神经元L型钙通道的影响]
[Effects of Bay K8644 and nifedipine on L-type Ca2+ channels in hypothalamic neurons of rats].
作者信息
Fu Q J, Zou F
机构信息
Department of Thermal Environment Medicine, First Military Medical University, Guangzhou 510515.
出版信息
Sheng Li Xue Bao. 2001 Oct;53(5):339-43.
PMID:11833415
Abstract
To investigate the effects of Bay K8644 and nifedipine on L-type of Ca2+ channels in hypothalamic neurons, the cell-attached patch-clamp technique was used to record Ca2+ current from isolated neurons. The results showed that the averaged open time and NPo were markedly increased by Bay K8644, but had no effect on channel conductance. Nifedipine, on the contrary, had an inhibitory effect on the L-type Ca2+ channels.
摘要
为研究Bay K8644和硝苯地平对下丘脑神经元L型Ca2+通道的影响，采用细胞吸附式膜片钳技术记录分离神经元的Ca2+电流。结果显示，Bay K8644可显著增加平均开放时间和NPo，但对通道电导无影响。相反，硝苯地平对L型Ca2+通道有抑制作用。
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