Wielosz M, Młynarczyk M, Kleinrok Z
Department of Pharmacology, Medical Academy, Lublin, Poland.
Pol J Pharmacol. 1997 Sep-Oct;49(5):369-71.
The study was designed to investigate the effects of administration of cholinomimetic agents and nifedipine on seizures induced by BAY k-8644 in rats. Injection of pilocarpine (3 mg/kg) increased seizures induced by BAY k-8644 (2 mg/kg). Administration of nifedipine (10 mg/kg) did not affect the convulsions and mortality elicited by coadministration of BAY k-8644 and pilocarpine. However, the facilitating effect of pilocarpine on BAY k-8644-induced seizures was fully prevented by pretreatment of rats with a cholinergic antagonist atropine (5 mg/kg). No similar effects were observed after injection of another cholinomimetic agent physostigmine (0.3 mg/kg). This finding implies, that facilitation of convulsant action of BAY k-8644 by pilocarpine may be related to activity of cholinergic system, but not strictly to activity of voltage dependent calcium channels.
该研究旨在调查拟胆碱药和硝苯地平对BAY k-8644诱导的大鼠癫痫发作的影响。注射毛果芸香碱（3毫克/千克）会增加BAY k-8644（2毫克/千克）诱导的癫痫发作。给予硝苯地平（10毫克/千克）对BAY k-8644和毛果芸香碱共同给药引起的惊厥和死亡率没有影响。然而，用胆碱能拮抗剂阿托品（5毫克/千克）预处理大鼠可完全阻止毛果芸香碱对BAY k-8644诱导的癫痫发作的促进作用。注射另一种拟胆碱药毒扁豆碱（0.3毫克/千克）后未观察到类似效果。这一发现表明，毛果芸香碱对BAY k-8644惊厥作用的促进可能与胆碱能系统的活性有关，但并不严格与电压依赖性钙通道的活性有关。
