Hammond P
Exp Brain Res. 1975 Aug 14;23(2):113-28. doi: 10.1007/BF00235454.
Receptive field organization of 135 sustained and 45 transient retinal ganglion cells was investigated in lightly pentobarbitone-anaesthetised cats. Stimuli were concentric annuli presented alone or simultaneously with a small spot centred on the receptive field, against photopic, mesopic or scotopic backgrounds. The addition of the test spot led to reduction in diameter of the centre-surround boundary of receptive fields of sustained retinal ganglion cells (assessed with annuli), and a decrease in diameter of the annulus which was most effective on the surround. In transient cells there was only marginal reduction in diameter of the centre-surround boundary, measured with annuli, and little or no decrease in diameter of the most effective annulus. Reducing background intensity from photopic to scotopic induced changes in response patterns and receptive field organization of sustained and transient retinal ganglion cells which were independent of stimulus intensity. Against photopic backgrounds, large annuli evoked surround-type responses from the majority of transient ganglion cells and from all sustained cells. In the scotopic range, surround-type responses could still be evoked from sustained cells, whereas predominantly centre-type responses were obtained throughout the receptive fields of transient cells. With transition from cone to rod vision, receptive field surrounds of sustained and transient cells became progressively less responsive than centres; in consequence the diameter of the centre-surround boundary increased. The initial, high frequency burst of impulses in discharges at annulus onset or offset became less evident and response latency increased substantially. The results are consistent with a model in which the centre and surround receptive field mechanisms are spatially co-extensive in transient retinal ganglion cells, albeit of different shape, but only partially overlapping in sustained retinal ganglion cells. It is suggested that the surround mechanism in sustained cells is spatially more extensive than the centre mechanism but does not extend entirely through the centre of the field.
在轻度戊巴比妥麻醉的猫中，研究了135个持续性和45个瞬态视网膜神经节细胞的感受野组织。刺激物为同心环，单独呈现或与位于感受野中心的小点同时呈现，背景为明视、中间视觉或暗视背景。添加测试点导致持续性视网膜神经节细胞感受野（用环评估）的中心-周边边界直径减小，以及对周边最有效的环的直径减小。在瞬态细胞中，用环测量的中心-周边边界直径仅略有减小，最有效环的直径几乎没有减小或没有减小。将背景强度从明视降低到暗视会引起持续性和瞬态视网膜神经节细胞的反应模式和感受野组织的变化，这些变化与刺激强度无关。在明视背景下，大多数瞬态神经节细胞和所有持续性细胞对大环产生周边型反应。在暗视范围内，持续性细胞仍可诱发周边型反应，而在瞬态细胞的整个感受野中主要获得中心型反应。随着从锥体细胞视觉向杆体细胞视觉的转变，持续性和瞬态细胞的感受野周边比中心的反应性逐渐降低；因此，中心-周边边界的直径增加。环开始或结束时放电中最初的高频冲动爆发变得不那么明显，反应潜伏期大幅增加。结果与一个模型一致，在该模型中，瞬态视网膜神经节细胞的中心和周边感受野机制在空间上是共同扩展的，尽管形状不同，但在持续性视网膜神经节细胞中仅部分重叠。有人认为，持续性细胞中的周边机制在空间上比中心机制更广泛，但并不完全延伸到视野中心。
