Huang W, Yang Y, Wu S, Jin Z, Bao D, Gan H
Department of Emergency, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou 310016, China.
Chin J Traumatol. 2001 Aug;4(3):161-3.
To study the changes and clinical significance of arginine vasopressin (AVP) and angiotensin II (AT-II) in patients with acute moderate and severe cerebral injury.
The early plasma concentration was checked by radioimmunoassay in 47 cases of acute moderate and severe cerebral injury, 30 cases of non-cerebral injury and 30 healthy volunteers.
The early plasma concentrations of AVP (50.23 ng/L +/- 15.31 ng/L) and AT-II (248.18 ng/L +/- 82.47 ng/L) in cerebral injury group were higher than those in non-cerebral injury group (AVP for 30.91 ng/L +/- 11.48 ng/L and AT-II for 120.67 ng/L +/- 42.49 ng/L, P<0.01). The early plasma concentrations of AVP and AT-II in cerebral injury group were also obviously higher than those of the volunteers (AVP for 5.16 ng/L +/- 4.23 ng/L and AT-II for 43.11 ng/L +/- 16.39 ng /L, P<0.001). At the same time, the early plasma level of AVP (58.90 ng/L +/- 18.12 ng/L) and AT-II (292.13 ng/L +/- 101.17 ng/ L) was higher in severe cerebral injured patients than moderate cerebral injured ones (AVP for 36.68 ng/L +/- 12.16 ng/L and AT-II for 201.42 ng/L +/- 66.10 ng/L, P<0.01). The early level of AVP and AT-II was negatively related to the GCS scales in acute cerebral injury. The early plasma concentrations of AVP (45.98 ng/L +/- 13.48 ng/L) and AT-II (263. 28 ng/L +/- 80.23 ng/L) were lower in epidural hematoma group than those of subdural hematoma and cerebral injury group (AVP for 64.12 ng/L +/- 15.56 ng /L and AT-II for 319.82 ng/L +/- 108.11 ng/L, P<0. 01).
AVP and AT-II may play an important role in pathophysiologic process in the secondary cerebral injury. The more severe the cerebral injury is, the higher the early level of AVP and AT-II will be. The early plasma level of AVP and AT-II may be one of the severity indexes of cerebral injury.
研究急性中、重度脑损伤患者精氨酸加压素（AVP）和血管紧张素II（AT-II）的变化及其临床意义。
采用放射免疫法检测47例急性中、重度脑损伤患者、30例非脑损伤患者及30例健康志愿者的早期血浆浓度。
脑损伤组早期血浆AVP浓度（50.23 ng/L±15.31 ng/L）和AT-II浓度（248.18 ng/L±82.47 ng/L）高于非脑损伤组（AVP为30.91 ng/L±11.48 ng/L，AT-II为120.67 ng/L±42.49 ng/L，P<0.01）。脑损伤组早期血浆AVP和AT-II浓度也明显高于志愿者组（AVP为5.16 ng/L±4.23 ng/L，AT-II为43.11 ng/L±16.39 ng/L，P<0.001）。同时，重度脑损伤患者早期血浆AVP浓度（58.90 ng/L±18.12 ng/L）和AT-II浓度（292.13 ng/L±101.17 ng/L）高于中度脑损伤患者（AVP为36.68 ng/L±12.16 ng/L，AT-II为201.42 ng/L±66.10 ng/L，P<0.01）。急性脑损伤时AVP和AT-II的早期水平与格拉斯哥昏迷量表评分呈负相关。硬膜外血肿组早期血浆AVP浓度（45.98 ng/L±13.48 ng/L）和AT-II浓度（263.28 ng/L±80.23 ng/L）低于硬膜下血肿组和脑损伤组（AVP为64.12 ng/L±15.56 ng/L，AT-II为319.82 ng/L±108.11 ng/L，P<0.01）。
AVP和AT-II可能在继发性脑损伤的病理生理过程中起重要作用。脑损伤越严重，AVP和AT-II的早期水平越高。AVP和AT-II的早期血浆水平可能是脑损伤严重程度的指标之一。
