Baas Paul
Department of Thoracic Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Semin Oncol. 2002 Feb;29(1):62-9. doi: 10.1053/sonc.2002.30231.
It has been a challenge to find effective chemotherapeutic treatments for malignant mesothelioma. Over the last several decades numerous single-drug and combination regimens have been examined, but no standard treatment with chemotherapy alone has emerged. Possible explanations for this lack of success are the heterogeneity between the different subclasses of mesothelioma and the difficulties experienced in determining responses on computed tomographic (CT) scan. This review will present the results of most chemotherapy trials. An attempt is also been made to overcome the problem of identifying the overall response rate by presenting the median survival time. Other types of response evaluation and guidelines for patient selection are warranted to properly compare chemotherapeutic treatments.
寻找有效的恶性间皮瘤化疗方案一直是一项挑战。在过去几十年里，人们对众多单药和联合用药方案进行了研究，但尚未出现仅用化疗的标准治疗方案。间皮瘤不同亚类之间的异质性以及在计算机断层扫描（CT）上确定反应所遇到的困难，可能是导致这种治疗失败的原因。本综述将呈现大多数化疗试验的结果。还尝试通过给出中位生存时间来克服确定总缓解率的问题。为了正确比较化疗方案，有必要采用其他类型的反应评估方法和患者选择指南。
