Matous B, Pavel S, Budĕsínská A, Duchon J, Mechl Z, Sopková B
Neoplasma. 1979;26(5):597-602.
Urinary melanogens are indolic and phenolic compounds which are excreted in an elevated amount in the urine of melanoma patients. Urinary melanogens can be divided into two principal groups according to their behavior during Thormählen test--Thormählen positive melanogens (TPM) and Thormählen negative melanogens (TNM). When comparing TPM and TNM (represented by homovanillic and vanillactic acids) urinary excretion in stage III of melanoma patients we have found two significantly different relations for melanogens excretion, i. e. predominating TPM urinary excretion in melanotic forms of melanomas and predominating homovanillic acid and vanillactic acid urinary excretion in amelanotic forms of melanomas. We assumed that it could be an indirect evidence of the different catalytic activity of either cresolase or catecholase activities of tyrosinase.
尿黑素原是吲哚类和酚类化合物，在黑色素瘤患者尿液中的排泄量会升高。根据其在托姆ählen试验中的表现，尿黑素原可分为两个主要类别——托姆ählen阳性黑素原（TPM）和托姆ählen阴性黑素原（TNM）。在比较黑色素瘤患者III期的TPM和TNM（以高香草酸和香草乳酸表示）尿排泄情况时，我们发现黑素原排泄存在两种显著不同的关系，即黑色素性黑色素瘤中TPM尿排泄占主导，而无黑色素性黑色素瘤中高香草酸和香草乳酸尿排泄占主导。我们推测这可能是酪氨酸酶的甲酚酶或儿茶酚酶活性具有不同催化活性的间接证据。
