Matous B, Cigánek E F, Budĕsínská A, Duchon J
Neoplasma. 1987;34(1):77-84.
The excretion of Thormählen positive melanogens (TPM), zincuria, serum dopaoxidase activity of tyrosinase and serum sialic acid were determined in 60 patients with primary and/or metastatic cutaneous melanoma and in 20 healthy persons. On the basis of our results we can recommend the following of TPM urinary excretion and serum dopaoxidase activity in the course of malignant melanoma as specific markers of the tumor growth. The following of serum sialic acid in the course of malignant melanoma is valuable from the standpoint of prognosis of the disease. The following of zincuria in the course of malignant melanoma is not recommended because of its low value for monitoring melanoma patients.
对60例原发性和/或转移性皮肤黑色素瘤患者及20名健康人测定了托姆ählen阳性黑素原（TPM）的排泄、尿锌、酪氨酸酶的血清多巴氧化酶活性和血清唾液酸。根据我们的结果，我们可以推荐在恶性黑色素瘤病程中监测TPM尿排泄和血清多巴氧化酶活性，作为肿瘤生长的特异性标志物。从疾病预后的角度来看，在恶性黑色素瘤病程中监测血清唾液酸是有价值的。由于监测黑色素瘤患者时其价值较低，不建议在恶性黑色素瘤病程中监测尿锌。
