Liesegang Thomas J
Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida 32224, USA.
CLAO J. 2002 Jan;28(1):12-27.
This article reviews the corneal changes resulting from the hypoxia that occurs during sleep and specifically during contact lens wear.
Discussion includes a literature review and observations regarding the changes to the corneal epithelium, stroma, and endothelium that take place during sleep and wearing of contact lenses made from different materials.
Hypoxia and hypercapnia cause significant changes to the corneal epithelium, stroma, and endothelium. Some of these changes can also be seen following the sleep cycle. Epithelial changes include decreased metabolic rate, morphologic changes, microcysts, changes in junctional integrity, decreased corneal sensation, and pannus formation. Stromal changes include stromal edema, stromal acidosis, neovascularization, and changes in corneal shape and, ultimately, corneal thinning. Endothelial changes include bleb formation, polymegethism, changes in endothelial cell density, and possible changes in endothelial function.
There are multiple and significant corneal changes resulting from hypoxia and hypercapnia. These changes vary with the specific lens style. The high-oxygen-permeable contact lenses recently introduced may overcome some of these problems.
本文综述睡眠期间尤其是佩戴隐形眼镜期间发生的缺氧所导致的角膜变化。
讨论内容包括文献综述以及关于睡眠期间和佩戴由不同材料制成的隐形眼镜期间角膜上皮、基质和内皮所发生变化的观察结果。
缺氧和高碳酸血症会导致角膜上皮、基质和内皮发生显著变化。其中一些变化在睡眠周期后也可见。上皮变化包括代谢率降低、形态学改变、微囊肿、连接完整性改变、角膜感觉减退和血管翳形成。基质变化包括基质水肿、基质酸中毒、新生血管形成、角膜形状改变以及最终的角膜变薄。内皮变化包括小泡形成、大小不均、内皮细胞密度改变以及内皮功能可能的变化。
缺氧和高碳酸血症会导致多种显著的角膜变化。这些变化因特定的镜片类型而异。最近推出的高透氧隐形眼镜可能会克服其中一些问题。
