Departments of Pharmacology, Physiology and Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA.
Department of Biochemistry and Cell Biology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA; Department of Ophthalmology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, 02118, USA.
Ocul Surf. 2023 Oct;30:85-91. doi: 10.1016/j.jtos.2023.08.008. Epub 2023 Aug 30.
Maintaining the clarity of the cornea is essential for vision, and is achieved through an exquisite array of collagen fibrils and proteoglycans in the corneal stroma. Alterations in the identity and modifications of the glycosaminoglycans (GAGs) are seen both throughout the normal wound healing process and in pathological conditions resulting in corneal opacity. Understanding these changes has been essential for the development of corneal prostheses and corneal reconstruction. The goal of this review article is to summarize and consolidate research in the alterations seen in glycosaminoglycans in injured and hypoxic states, address the role of proteins that can regulate glycosaminoglycans in the corneal wound healing process, and apply these findings to the context of corneal restoration through reconstruction or the insertion of synthetic devices.
保持角膜的清晰度对于视力至关重要，这是通过角膜基质中精细排列的胶原纤维和蛋白聚糖实现的。在正常的伤口愈合过程中和导致角膜混浊的病理条件下，都可以看到糖胺聚糖 (GAG) 的身份改变和修饰。了解这些变化对于角膜假体和角膜重建的发展至关重要。本文综述的目的是总结和整合在受伤和缺氧状态下 GAG 变化的研究，探讨可调节角膜伤口愈合过程中 GAG 的蛋白质的作用，并将这些发现应用于通过重建或插入合成装置来恢复角膜的背景下。
