Vasil'ev A P, Strel'tsova N N, Gorbunova T Iu, Dubova T V
Klin Med (Mosk). 2001;79(12):13-6.
50 patients with postinfarction cardiosclerosis and angina pectoris (functional class I-IV) having left ventricular ejection fraction < 45% entered a comparative cross-over trial of antianginal effectiveness of anaprilin and carvediolol (dilatrend). In 10 patients carvedilol was compared to placebo. Carvedilol is shown to demonstrate higher antianginal activity which is the highest in patients with angina pectoris of low load. The analysis of peripheral vascular resistance and double product attributes antianginal advantages of carvedilol to its more potent effect on cardiac performance due to peripheral vasodilatation.
50例心肌梗死后心硬化和心绞痛（功能分级I-IV级）且左心室射血分数<45%的患者进入了阿普洛尔和卡维地洛（达利全）抗心绞痛效果的比较交叉试验。10例患者将卡维地洛与安慰剂进行了比较。结果显示卡维地洛具有更高的抗心绞痛活性，在低负荷心绞痛患者中活性最高。对外周血管阻力和双乘积的分析表明，卡维地洛的抗心绞痛优势归因于其通过外周血管舒张对心脏功能产生的更强作用。
