Bolli G, Cartechini M G, Compagnucci P, Massi-Benedetti M, Filipponi P, Nicoletti I, De Feo P, Angeletti G
Minerva Med. 1979 Dec 8;70(55):3783-95.
In an assessment of the degree of adrenergic activity in the course of diabetes mellitus, plasma levels and urinary excretion of norepinephrine and epinephrine were determined in 20 normal subjects and 47 diabetics: 11 in good control (group I), 23 in poor control (group II), 13 with frank ketoacidosis (group III). The study was repeated in groups II and III once good glycometabolic control had been achieved. Slightly above normal catecholamine levels were noted in group I, while there was a marked increase in group II. Group III shaved an enormous increase by comparison with the other two groups. After medical treatment values in group III fell to within the group I range. The conclusion is drawn that a close relationship exists between adrenergic acitivity and the degree of control of diabetes. The sympathetic nervous system, therefore, interferes in the course of diabetes with blood sugar control via numerous, complex mechanisms.
在一项对糖尿病病程中肾上腺素能活性程度的评估中，测定了20名正常人和47名糖尿病患者的血浆去甲肾上腺素和肾上腺素水平以及尿排泄量，其中糖尿病患者分为：血糖控制良好的11例（第一组），血糖控制不佳的23例（第二组），有明显酮症酸中毒的13例（第三组）。在第二组和第三组实现良好的糖代谢控制后，重复进行了该研究。第一组的儿茶酚胺水平略高于正常，而第二组则显著升高。与其他两组相比，第三组的儿茶酚胺水平大幅升高。经过药物治疗后，第三组的值降至第一组范围内。得出的结论是，肾上腺素能活性与糖尿病控制程度之间存在密切关系。因此，交感神经系统通过多种复杂机制干扰糖尿病病程中的血糖控制。
