Bolli G, Compagnucci P, Cartechini M G, De Feo P, Santeusanio F, Puxeddu A, Brunetti P
Acta Diabetol Lat. 1979 Apr-Jun;16(2):157-67. doi: 10.1007/BF02581095.
Sympathetic activity was determined in 13 ketoacidotic diabetics by evaluation of plasma and urinary catecholamines, before and in the course of medical management. Patients were divided into two groups. Group A (severe ketoacidosis, n = 5) and Group B (moderate ketoacidosis, = 8), depending on plasma glucose, pH and plasma bicarbonate levels. The results showed an enhanced sympathetic activity in all patients before treatment, with significant decrease during therapy. In Group A plasma catecholamines were higher than in Group B, both before and in the course of therapy. A significant correlation was found between basal plasma catecholamines and initial plasma glucose, plasma bicarbonate, hours of therapy and insulin dosage required to obtain plasma glucose levels below 150 mg/100 ml .These results, suggesting a close correlation between glycometabolic control and adrenergic activity, emphasize the role of the sympathetic nervous system as a powerful contrainsular factor in the pathogenesis and metabolic derangement of diabetic ketoacidosis.
通过评估血浆和尿儿茶酚胺，在13例酮症酸中毒糖尿病患者药物治疗前及治疗过程中测定交感神经活动。患者分为两组。根据血糖、pH值和血浆碳酸氢盐水平，A组（重度酮症酸中毒，n = 5）和B组（中度酮症酸中毒，n = 8）。结果显示，所有患者治疗前交感神经活动增强，治疗期间显著降低。治疗前及治疗过程中，A组血浆儿茶酚胺均高于B组。基础血浆儿茶酚胺与初始血糖、血浆碳酸氢盐、治疗时间以及使血糖水平降至150 mg/100 ml以下所需胰岛素剂量之间存在显著相关性。这些结果表明糖代谢控制与肾上腺素能活动密切相关，强调了交感神经系统在糖尿病酮症酸中毒发病机制和代谢紊乱中作为强大的抗胰岛因素的作用。
