Scarpelli P T, Pieri A, Rizzo M, Boccuni M
Int Urol Nephrol. 1975;7(2):157-70. doi: 10.1007/BF02085436.
Small cutaneous vessels, obtained by ear lobe biopsies, were studied in 14 patients with various chronic nephritides and in 10 normal controls. The capillaries in the group of patients with nephritis were found to undergo two main changes: thickening of the adventitia reticularis and perivascular cellular infiltration in an inverse ratio. This infiltration was seen to be made up of mononuclear cells and an increased number of mast cells in various stages of degranulation. Changes in the basement membrane as seen by electron microscopy are not constant. All of the above changes were absent in the controls and are similar to what has been described in previous studies in both experimental and spontaneous pathologic conditions, such as experimental hypertension, diabetes mellitus, scleroderma, rheumatoid arthritis, etc. Small vessel involvement in chronic nephritides could be part of a process of diffuse microvascular damage that includes the kidneys or it may be related to hypertension or to the biochemical changes which follow uremic and pre-uremic states.
对通过耳垂活检获取的小皮肤血管进行了研究，研究对象为14例患有各种慢性肾炎的患者和10名正常对照者。发现肾炎患者组的毛细血管发生了两种主要变化：外膜网状层增厚和血管周围细胞浸润呈反比。这种浸润由单核细胞和数量增加的处于不同脱颗粒阶段的肥大细胞组成。电子显微镜下所见的基底膜变化并不恒定。对照组未出现上述所有变化，且这些变化与先前在实验性和自发性病理状况（如实验性高血压、糖尿病、硬皮病、类风湿性关节炎等）研究中所描述的情况相似。慢性肾炎中的小血管受累可能是包括肾脏在内的弥漫性微血管损伤过程的一部分，或者可能与高血压或尿毒症及尿毒症前期状态后的生化变化有关。
