Sloan W R, Coffey D S, Scott W W
Invest Urol. 1975 Sep;13(2):90-4.
A new animal model has been developed for studying the effects of nonhormonal drugs on the androgen-induced growth of the rat prostate. The antimetabolite 5-fluorouracil caused a 60 per cent reduction of the rate of prostatic DNA synthesis in androgen-stimulated castrate rats. This drug did not decrease the size of the prostate in normal intact animals and did not exhibit significant antiandrogenic activity. Its distribution is primarily in the acid-soluble fraction of the total prostatic homogenate.
已开发出一种新的动物模型，用于研究非激素药物对雄激素诱导的大鼠前列腺生长的影响。抗代谢物5-氟尿嘧啶使雄激素刺激的去势大鼠前列腺DNA合成速率降低了60%。这种药物在正常完整动物中不会减小前列腺的大小，也不表现出显著的抗雄激素活性。其分布主要在前列腺总匀浆的酸溶性部分。
